Biopharmaceutical Modeling of Drug Supersaturation During Lipid-Based Formulation Digestion Considering an Absorption Sink
نویسندگان
چکیده
منابع مشابه
Enhanced supersaturation and oral absorption of sirolimus using an amorphous solid dispersion based on Eudragit® e.
The present study aimed to investigate the effect of Eudragit® E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral bioavailability. Sirolimus-loaded solid dispersions were fabricated by a spray drying process. A kinetic solubility test demonstrated that the sirolimus/E-SD...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2014
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-014-1432-1